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supplement – Redcon1 Online Official https://redcon1online.com The Highest State of Readiness Mon, 24 Jul 2017 17:30:11 +0000 en-US hourly 1 https://wordpress.org/?v=6.5.2 Three Different Forms of Creatine in Tango For Ultimate Recovery https://redcon1online.com/tango-ultimate-recovery/ Tue, 25 Jul 2017 04:00:10 +0000 https://redcon1online.com/?p=4323 Today, I wanted to actually focus on a specific product from RedCon1 called Tango which is a recovery based product that includes three different forms of creatine, betaine anhydrous, taurine, and l-ornithine l-aspartate in a 13.4 gram scoop per serving. Before we even dig into these ingredients I would like to point out the fact that this product, like all RedCon1 products, contain clinical dosages meaning that they are dosed according to what the research has found to be optimal. Creatine typically is recommended around 3-5 grams per day. This formula contains 7 grams total. Betaine Anhydrous is dosed perfectly at about 2.5 grams as well as taurine and l-ornithine l-aspartate. The big drawing point of this product for overall recovery and growth is that blend of three different forms of creatine. We know that creatine is a molecule that can rapidly produce energy (ATP) to support cellular function and is one of the most well known and supported ergogenic aids on the market with over 800 studies conducted on its efficacy. Creatine is known to increase intra-muscular cellular hydration, weight, power output, endurance, reduces fatigue levels, and the list goes on and on. The International Society of Sports Nutrition has a meta analysis of over 100 studies with the following position stance:

1. Creatine monohydrate is the most effective ergogenic nutritional supplement currently available to athletes in terms of increasing high-intensity exercise capacity and lean body mass during training.

2. Creatine monohydrate supplementation is not only safe, but possibly beneficial in regard to preventing injury and/or management of select medical conditions when taken within recommended guidelines.

3. There is no scientific evidence that the short- or long-term use of creatine monohydrate has any detrimental effects on otherwise healthy individuals.

4. If proper precautions and supervision are provided, supplementation in young athletes is acceptable and may provide a nutritional alternative to potentially dangerous anabolic drugs.

5. At present, creatine monohydrate is the most extensively studied and clinically effective form of creatine for use in nutritional supplements in terms of muscle uptake and ability to increase high-intensity exercise capacity.

6. The addition of carbohydrate or carbohydrate and protein to a creatine supplement appears to increase muscular retention of creatine, although the effect on performance measures may not be greater than using creatine monohydrate alone.

7. The quickest method of increasing muscle creatine stores appears to be to consume ~0.3 grams/kg/day of creatine monohydrate for at least 3 days followed by 3–5 g/d thereafter to maintain elevated stores. Ingesting smaller amounts of creatine monohydrate (e.g., 2–3 g/d) will increase muscle creatine stores over a 3–4 week period, however, the performance effects of this method of supplementation are less supported.

8. Creatine products are readily available as a dietary supplement and are regulated by the U.S. Food and Drug Administration (FDA). Specifically, in 1994, U.S. President Bill Clinton signed into law the Dietary Supplement Health and Education Act (DSHEA). DSHEA allows manufacturers/companies/brands to make structure-function claims; however, the law strictly prohibits disease claims for dietary supplements.

9. Creatine monohydrate has been reported to have a number of potentially beneficial uses in several clinical populations, and further research is warranted in these areas.

Even further more than the ISSN’s position stance is the fact that Tango includes Creatine Monohydrate, Creatine HCL, and Magnesium Creatine Chelate. Creatine monohydrate is the most basic and well research form of creatine on the market where has creatine HCL is a newer version of creatine that is water soluble and there by more easily absorbed into the bloodstream. Creatine HCL also has been noted to give fewer sides effects mainly due to the fact that its more potent and thus you need less (5 grams compared to only 1 gram.) Finally we have Magnesium Creatine Chelate which depends on magnesium for intramuscular absorption rather than water.  Theres actually a very interesting bit of research on it from Ashmead et al on the synergists effects of magesnium and creatine on ergogenic performance in rats. They state “Supplements of either magnesium or creatine have been previously reported to improve ergogenic performance. This study compared ergogenic activity and recovery in rats by swimming them to exhaustion, resting them for 30 minutes, and then re-swimming them to exhaustion after previously receiving no creatine supplementation, creatine monohydrate (CM) alone, CM plus MgO, CM plus Mg amino acid chelate, or Mg creatine chelate supplements for 8 days. Daily doses of Mg and creatine were 5 mg and 100 mg, respectively, per kg body weight. The source of the Mg appeared to affect ergogenic performance. The Mg creatine chelate not only resulted in significantly (P < 0.01) greater swimming time to exhaustion, but it was the only Mg source that resulted in significant (P < 0.05) ergogenic recovery during the second swimming period. It was concluded that when Mg was chelated to CM in a 1:1 molar ratio, the resulting molecule allowed greater ergogenic activity than when the metabolites were supplied as admixtures with Mg coming from other sources” (2.)

If its not already abundantly clear, creatine in all its forms is extremely beneficial. But now we have these creatine blends on the market that seem to enhance an already effective product! Not to mention Tango has MORE than just creatine to aid in overall ATP production, hypertrophy support, and recovery. I feel these specific kinds of products are often overlooked as being just another creatine product but that couldn’t be further from the truth. I recommend you conduct your own research to learn more about the benefits of blending creatine products as there is more than enough sources out there.

Alex Kikel

MS, PES, CPT, Speed and Explosion Specialist Level II

Owner of www.theprepcoach.com

References

  1. International Society of Sports Nutrition position stand: creatine supplementation and exercise. Buford, T. W., Kreider, R. B., Stout, J. R., Greenwood, M., Campbell, B., Spano, M., … Antonio, J. (2007). Journal of the International Society of Sports Nutrition. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048496/)
  2. Synergestic Effects of Magnesium and Creatine on Ergogenic Performance in Rats. Ashmead et al. Journal of applied research. (http://jrnlappliedresearch.com/articles/Vol3Iss1/ASHMEAD.htm)
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Is Beta Alanine In YOUR Preworkout?! https://redcon1online.com/beta-alanine-preworkout/ Mon, 24 Jul 2017 17:11:05 +0000 https://redcon1online.com/?p=4320 Beta Alanine is an ingredient that is very popular in the supplement community but really isn’t discussed very much (and sadly usually isn’t dosed properly in many formulas on the market.) I think you should not only know what beta alanine is but also what it does, why you want it, and which products actually have clinical dosages (or proper dosages for lack of a better term.) Beta-alanine, the building block of carnosine, helps buffer acid in muscles and increases physical performance in the 60–240-second range. When beta-alanine is ingested, it turns into carnosine, which acts as that acid buffer. Carnosine is stored in cells and released in response to drops in pH. Paresthesia, the tingling feeling, can be caused by bigger dosages of beta alanine but it is simply a harmless side effect that usually disappears with usage. Beta Alanine has been shown to aid in increasing power, endurance, and reducing time to fatigue (along with a number of other benefits.)

Increased power output from muscle carnosine was shown by one of the more popular studies from Baguet et al in rowing performance. Chronic oral β-alanine supplementation is shown to elevate muscle carnosine content and improve anaerobic exercise performance during some laboratory tests, mainly in the untrained. It remains to be determined whether carnosine loading can improve single competition-like events in elite athletes. The aims of the present study were to investigate if performance is related to the muscle carnosine content and if β-alanine supplementation improves performance in highly trained rowers. Eighteen Belgian elite rowers were supplemented for 7 wk with either placebo or β-alanine (5 g/day). Before and following supplementation, muscle carnosine content in soleus and gastrocnemius medialis was measured by proton magnetic resonance spectroscopy ((1)H-MRS) and the performance was evaluated in a 2,000-m ergometer test. At baseline, there was a strong positive correlation between 100-, 500-, 2,000-, and 6,000-m speed and muscle carnosine content. After β-alanine supplementation, the carnosine content increased by 45.3% in soleus and 28.2% in gastrocnemius. Following supplementation, the β-alanine group was 4.3 s faster than the placebo group, whereas before supplementation they were 0.3 s slower (P = 0.07). Muscle carnosine elevation was positively correlated to 2,000-m performance enhancement (P = 0.042 and r = 0.498). It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and the positive correlation between changes in muscle carnosine and performance improvement suggest that muscle carnosine is a new determinant of rowing performance (1.)

Hobson et al conducted a very important bit of literature on beta alanine supplementation and its direct effects on exercise performance in a meta analysis. They stated that “due to the well-defined role of β-alanine as a substrate of carnosine (a major contributor to H+ buffering during high-intensity exercise), β-alanine is fast becoming a popular ergogenic aid to sports performance. There have been several recent qualitative review articles published on the topic, and here we present a preliminary quantitative review of the literature through a meta-analysis. A comprehensive search of the literature was employed to identify all studies suitable for inclusion in the analysis; strict exclusion criteria were also applied. Fifteen published manuscripts were included in the analysis, which reported the results of 57 measures within 23 exercise tests, using 18 supplementation regimes and a total of 360 participants [174, β-alanine supplementation group (BA) and 186, placebo supplementation group (Pla)]. BA improved (P=0.002) the outcome of exercise measures to a greater extent than Pla [median effect size (IQR): BA 0.374 (0.140-0.747), Pla 0.108 (-0.019 to 0.487)]. Some of that effect might be explained by the improvement (P=0.013) in exercise capacity with BA compared to Pla; no improvement was seen for exercise performance (P=0.204). In line with the purported mechanisms for an ergogenic effect of β-alanine supplementation, exercise lasting 60-240 s was improved (P=0.001) in BA compared to Pla, as was exercise of >240 s (P=0.046). In contrast, there was no benefit of β-alanine on exercise lasting <60 s (P=0.312). The median effect of β-alanine supplementation is a 2.85% (-0.37 to 10.49%) improvement in the outcome of an exercise measure, when a median total of 179 g of β-alanine is supplemented” (2.)

Finally, we’ll conclude on its ability to reduce fatigue from the works of Hoffman et al. The purpose of this study was to examine the effect of 30 days of beta-alanine supplementation in collegiate football players on anaerobic performance measures. Subjects were randomly divided into a supplement (beta-alanine group [BA], 4.5 g x d(-1) of beta-alanine) or placebo (placebo group [P], 4.5 g x d(-1) of maltodextrin) group. Supplementation began 3 weeks before preseason football training camp and continued for an additional 9 days during camp. Performance measures included a 60-second Wingate anaerobic power test and 3 line drills (200-yd shuttle runs with a 2-minute rest between sprints) assessed on day 1 of training camp. Training logs recorded resistance training volumes, and subjects completed questionnaires on subjective feelings of soreness, fatigue, and practice intensity. No difference was seen in fatigue rate in the line drill, but a trend (P = .07) was observed for a lower fatigue rate for BA compared with P during the Wingate anaerobic power test. A significantly higher training volume was seen for BA in the bench press exercise, and a trend (P = .09) for a greater training volume was seen for all resistance exercise sessions. In addition, subjective feelings of fatigue were significantly lower for BA than P. In conclusion, despite a trend toward lower fatigue rates during 60 seconds of maximal exercise, 3 weeks of beta-alanine supplementation did not result in significant improvements in fatigue rates during high-intensity anaerobic exercise. However, higher training volumes and lower subjective feelings of fatigue in BA indicated that as duration of supplementation continued, the efficacy of beta-alanine supplementation in highly trained athletes became apparent (3.)

It is clear that beta alanine is a supplement that is beyond beneficial for any athletic endeavor! In these studies, we see a wide array of dosages from 2 grams all the way up to 5 grams. It has been concluded that 3.2 grams of beta alanine is the accepted clinical dosage. If your taking a pre workout that has LESS than that clinical amount then you’re pretty much wasting your money as you will not reap the full benefits. Luckily, supplements like Total War from RedCon1 provide the full 3.2 gram clinical dosage of beta alanine along with other great ergogenic aids like citrulline malate, agmatine sulfate, and a number of others ALL having the correct clinical dosage.

Alex Kikel

MS, PES, CPT, Speed and Explosion Specialist Level II

Owner of www.theprepcoach.com

References

  1. Important role of muscle carnosine in rowing performance. Audrey Baguet, Jan Bourgois, Lander Vanhee, Eric Achten, Wim Derave. J Appl Physiol (1985) 2010 (https://www.ncbi.nlm.nih.gov/pubmed/20671038)
  2. Effects of β-alanine supplementation on exercise performance: a meta-analysis. R. M. Hobson, B. Saunders, G. Ball, R. C. Harris, C. Sale. Amino Acids. 2012 (https://www.ncbi.nlm.nih.gov/pubmed/22270875)
  3. Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Jay R. Hoffman, Nicholas A. Ratamess, Avery D. Faigenbaum, Ryan Ross, Jie Kang, Jeffrey R. Stout, John A. Wise. Nutr Res. 2008 (https://www.ncbi.nlm.nih.gov/pubmed/19083385)
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Social Media’s Impact on Bodybuilding & Fitness https://redcon1online.com/social-medias-impact-bodybuilding-fitness/ Fri, 07 Jul 2017 04:00:26 +0000 https://redcon1online.com/?p=4156 If we compare the supplement industry from the 20th century to today, one significant variable is noticeably different, and that is the dawn and presence of social media. As we have progressed into the 21st century the advent and advancement of Facebook, Instagram, YouTube, Twitter, and Snapchat have mandated supplement companies and their athletes to post and interact on each platform. Further, due to the cost-effectiveness of marketing on social media, many low-budgeted supplement companies have emerged, as they are now able to reach their targeted market. Consequently, the competition in the supplement industry has been augmented. The early 2000’s where large supplement companies dominated the industry has gradually diminished. Now, social media has increased the opportunity for multiple companies to market their products and convey their views to their audience. However, now that numerous companies have emerged the question now becomes if the impact of social media is good or bad for the supplement industry.

One of the downfalls of social media’s ability to market supplement companies is the saturation of the supplement industry. You see a lot of these companies sprout at bodybuilding expos yearly and by the next year vanish, or if they are lucky, they stick around for a few more years. Various people, including myself, advocate for entrepreneurship and for people to live their dreams by creating their company. However, to be successful in the supplement industry, you have to provide value to your consumers. Countless companies who benefit from social media outlets hurt the business of the supplement industry by proving quantity rather than quality products. Even though some companies have the great work ethic to launch their products and establish their brand, if their product lacks the proper ingredient composition to produce results and taste well at the same time, then the company will likely not be around for much longer.

Now, for prudent and respectable supplement companies, the impact of social media can be beneficial, however, if they are not proactive then it can be detrimental. In the past few years various companies have emerged and as a result, have made the incoming revenue unpredictable and inconsistent. For this reason, now more than ever, supplement companies are now mindful of who they sponsor and their athlete’s reputation. Whomever the corporation chooses at their athlete, it is imperative for him or her to be active and engage with fans to establish a lucrative atmosphere that not only promotes the company but themselves as well. As the supplement industry has evolved, it has become evident that an athlete is not a trophy wife. Athletes must pull their end of the contract to be of value and produce for themselves as well as the company. If the commitment is not present, then their value decreases and the athlete becomes nothing more than a lagging muscle within the company.

Sponsored athletes need to be mindful of networking and establishing great relationships amongst athletes in their industry. Social media has allowed athletes to interact amongst each other and collaborate to develop or promote their brands. However, these interactions or relationships can create several drawbacks. Sponsored athletes and supplement companies are easily accessible to not only their fans but the fans of other athletes as well. If relationships among sponsored athletes and their fans take a turn for the worse, then social media warfare is inevitable. As a result, blemishes emerge not only on the athlete but on the supplement company he or she represents. In the 20th century, this would not have been an issue but as the supplement industry has evolved the impact of social media has been felt. Those who follow the bodybuilding/supplement industry understand the repercussions of an Order 66, fake weight claims, and racist comments. Therefore, being proactive, consistent, and honest is imperative to establish a loyal fan base that respects the athlete and the supplement company he or she represents.

Overall, the impact of social media on the supplement industry is both positive and negative while favoring those who are proactive and adapt to the constantly evolving industry. Supplement companies who are not tech savvy or do not use social media are at a disadvantage as the targeted market has developed a new ideology. Many of the consumers today receive their information from Facebook, Instagram, YouTube, Twitter, and Snapchat. Those who are unaware of this will lose in the industry. In the foreseeable future, this trend will likely continue, however, new trends are always emerging, therefore, it imperative to be attuned to the targeted market to develop new strategic plans to reach the consumer and win in the industry.

By: Robert E. Salazar MS (candidate), RDN

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Sulforaphane to Inhibit Myostatin? 2 https://redcon1online.com/sulforaphane-inhibit-myostatin-2/ Sat, 24 Jun 2017 04:00:29 +0000 https://redcon1online.com/?p=4052 With that in mind, we can move further onto its interactions with actual fat mass (directly correlated to its potential to increase the rate of lipolysis. Lee et al (4) looked at how sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway. “Sulforaphane, an aliphatic isothiocyanate derived from cruciferous vegetables, is known for its antidiabetic properties. The effects of sulforaphane on lipid metabolism in adipocytes are not clearly understood. Here, we investigated whether sulforaphane stimulates lipolysis. Mature adipocytes were incubated with sulforaphane for 24h and analyzed using a lipolysis assay which quantified glycerol released into the medium. We investigated gene expression of hormone-sensitive lipase (HSL), and levels of HSL phosphorylation and AMP-activated protein kinase on sulforaphane-mediated lipolysis in adipocytes. Sulforaphane promoted lipolysis and increased both HSL gene expression and HSL activation. Sulforaphane suppressed AMPK phosphorylation at Thr-172 in a dose-dependent manner, which was associated with a decrease in HSL phosphorylation at Ser-565, enhancing the phosphorylation of HSL Ser-563. Taken together, these results suggest that sulforaphane promotes lipolysis via hormone sensitive lipase activation mediated by decreasing AMPK signal activation in adipocytes.” To understand this more in depth I suggest reading the works of Garton et al as well as Gaidhu et al on “Identification and role of the basal phosphorylation site on hormone-sensitive lipase” and “5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes” (5, 6.)

Now, the moment you’ve been waiting for, MYOSTATIN INHIBITION! I’m sure many of you have skipped ahead to this part so I wont waste anymore time digging into the literature! Sulforaphane seems to repress myostatin transcription and suppression within skeletal muscle satellite cells. Fan et al discusses this relationship in great detail. Satellite cells function as skeletal muscle stem cells to support postnatal muscle growth and regeneration following injury or disease. There is great promise for the improvement of muscle performance in livestock and for the therapy of muscle pathologies in humans by the targeting of myostatin (MSTN) in this cell population. Human diet contains many histone deacetylase (HDAC) inhibitors, such as the bioactive component sulforaphane (SFN), whose epigenetic effects on MSTN gene in satellite cells are unknown. Therefore, we aimed to investigate the epigenetic influences of SFN on the MSTN gene in satellite cells. The present work provides the first evidence, which is distinct from the effects of trichostatin A (TSA), that SFN supplementation in vitro not only acts as a HDAC inhibitor but also as a DNA methyltransferase (DNMT) inhibitor in porcine satellite cells. Compared with TSA and 5-aza-2′-deoxycytidine (5-aza-dC), SFN treatment significantly represses MSTN expression, accompanied by strongly attenuated expression of negative feedback inhibitors of the MSTN signaling pathway. miRNAs targeting MSTN are not implicated in posttranscriptional regulation of MSTN. Nevertheless, a weakly enriched myoblast determination (MyoD) protein associated with diminished histone acetylation in the MyoD binding site located in the MSTN promoter region may contribute to the transcriptional repression of MSTN by SFN. These findings reveal a new mode of epigenetic repression of MSTN by the bioactive compound SFN. This novel pharmacological, biological activity of SFN in satellite cells may thus allow for the development of novel approaches to weaken the MSTN signaling pathway, both for therapies of human skeletal muscle disorders and for livestock production improvement (7.) Even furthermore CJ et al states “Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1). This work was undertaken to evaluate the effects of SFN on hepatic fibrosis and profibrotic transforming growth factor (TGF)-β/Smad signaling, which are closely associated with oxidative stress. SFN suppressed TGF-β-enhanced expression of α-smooth muscle actin (α-SMA), a marker of hepatic stellate cell (HSC) activation, and profibrogenic genes such as type I collagen, fibronectin, tissue inhibitor of matrix metalloproteinase (TIMP)-1, and plasminogen activator inhibitor (PAI)-1 in hTERT, an immortalized human HSC line. SFN inhibited TGF-β-stimulated activity of a PAI-1 promoter construct and (CAGA)(9) MLP-Luc, an artificial Smad3/4-specific reporter, in addition to reducing phosphorylation and nuclear translocation of Smad3. Nrf2 overexpression was sufficient to inhibit the TGF-β/Smad signaling and PAI-1 expression. Conversely, knockdown of Nrf2, but not inhibition of HO-1 or NQO1 activity, significantly abolished the inhibitory effect of SFN on (CAGA)(9) MLP-Luc activity. However, inhibition of NQO1 activity reversed repression of TGF-β-stimulated expression of type I collagen by SFN, suggesting the involvement of antioxidant activity of SFN in the suppression of Smad-independent fibrogenic gene expression. Finally, SFN treatment attenuated the development and progression of early stage hepatic fibrosis induced by bile duct ligation in mice, accompanied by reduced expression of type I collagen and α-SMA. Collectively, these results show that SFN elicits an antifibrotic effect on hepatic fibrosis through Nrf2-mediated inhibition of the TGF-β/Smad signaling and subsequent suppression of HSC activation and fibrogenic gene expression” (8.)

References

  1. Protein oxidation and aging. E. R. Stadtman. Science. 1992 (https://www.ncbi.nlm.nih.gov/pubmed/1355616)
  2. Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27. Nanqin Gan, Yu-Chieh Wu, Mathilde Brunet, Carmen Garrido, Fung-Lung Chung, Chengkai Dai, Lixin Mi. J Biol Chem. 2010 (https://www.ncbi.nlm.nih.gov/pubmed/20833711)
  3. Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Mi-Kyoung Kwak, Jeong-Min Cho, Bo Huang, Soona Shin, Thomas W. Kensler. Free Radic Biol Med. 2007 (https://www.ncbi.nlm.nih.gov/pubmed/17664144)
  4. Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway. Ju-Hee Lee, Myung-Hee Moon, Jae-Kyo Jeong, Yang-Gyu Park, You-Jin Lee, Jae-Won Seol, Sang-Youel Park. Biochem Biophys Res Commun. 2012 (https://www.ncbi.nlm.nih.gov/pubmed/22982310)
  5. Identification and role of the basal phosphorylation site on hormone-sensitive lipase. A. J. Garton, S. J. Yeaman. Eur J Biochem. 1990 (https://www.ncbi.nlm.nih.gov/pubmed/2165906)
  6. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced AMP-activated protein kinase phosphorylation inhibits basal and insulin-stimulated glucose uptake, lipid synthesis, and fatty acid oxidation in isolated rat adipocytes. Mandeep Pinky Gaidhu, Sergiu Fediuc, Rolando Bacis Ceddia. J Biol Chem. 2006 (https://www.ncbi.nlm.nih.gov/pubmed/16816404)
  7. Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells. Huitao Fan, Rui Zhang, Dawit Tesfaye, Ernst Tholen, Christian Looft, Michael Hölker, Karl Schellander, Mehmet Ulas Cinar. Epigenetics. 2012 (https://www.ncbi.nlm.nih.gov/pubmed/23092945)
  8. Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. Chang Joo Oh, Joon-Young Kim, Ae-Kyung Min, Keun-Gyu Park, Robert A. Harris, Han-Jong Kim, In-Kyu Lee. Free Radic Biol Med. 2012 (https://www.ncbi.nlm.nih.gov/pubmed/22155056)
  9. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. Purva Bali, Michael Pranpat, James Bradner, Maria Balasis, Warren Fiskus, Fei Guo, Kathy Rocha, Sandhya Kumaraswamy, Sandhya Boyapalle, Peter Atadja, et al. J Biol Chem. 2005 (https://www.ncbi.nlm.nih.gov/pubmed/15937340)
  10. Histone deacetylase inhibitors: signalling towards p21cip1/waf1. Matthias Ocker, Regine Schneider-Stock. Int J Biochem Cell Biol. 2007 (https://www.ncbi.nlm.nih.gov/pubmed/17412634)
  11. A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Melinda C. Myzak, P. Andrew Karplus, Fung-Lung Chung, Roderick H. Dashwood. Cancer Res. 2004 (https://www.ncbi.nlm.nih.gov/pubmed/15313918)
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Introduces Luke Lazenby – The New Tier Operator Manager https://redcon1online.com/tier-operator-manager/ Tue, 02 May 2017 19:56:12 +0000 https://redcon1online.com/?p=3472 https://youtu.be/NhNMcbheGP0

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Meal Prep 101- Part 3 https://redcon1online.com/meal-prep-3/ Sat, 29 Apr 2017 04:00:45 +0000 https://redcon1online.com/?p=3422 The first two parts of this series have went over the why meal prep is a great tool and how to store your food. This section will cover the nitty gritty and what to actually cook and store and eat. One thing to always to remember is how much water to drink along with the food and the importance of it. Always Have a bottle of water with you. Some vital facts of H20 to remember:

•Blood is 83% water

•Muscles are 75% water

•The brain is 74% water

•Bone is 22% water

It may feel like an annoyance at the beginning but having water with you will make a huge difference in your life. Water is a requirement. Your body needs water to digest and absorb vitamins and nutrients. Water also detoxifies the liver and kidneys, and carries away waste, and makes digestion possible. Fiber alone cannot aid proper digestive function. Feeling dehydrated? You may be, and not even know it! Without water, your blood is literally thicker, and your body has to work considerably tougher to cause it to circulate. Your brain becomes less active, it’s hard to concentrate, your body feels fatigued, and you just tire out. Aim for a gallon a day. Before you know it, you will start to crave and love your water. 

For best consistency eat meals every 2.5 to 3 hours apart, choose the right about of each food for your goals. You can buy a scale for $10-$20 bucks that will help you tremendously divide the food up with accuracy and speed. Divide all your meals into portion sizes for meals and storage. To speed up time in the kitchen I will cook a large amount of rice or sweet potatoes, and steam some green beans and/or broccoli while my meat is on the grill or in the oven. Make sure to keep spices handy when cooking meat to keep things different and more enjoyable. When choosing foods, try and pick ones that are low in the glycemic index, though there are many other healthy choices such as raisins, peas, corns, carrots, and white potatoes.

The last thing to mention that could make or break your success is the food that you choose to prep and cook. The richest sources of protein are animal foods such as chicken, meat, fish, cheese and eggs. However, plant proteins are believed to be healthier because of their lower fat content. Some of the best protein to eat from animals is turkey, fish. Chicken, steak. Once it comes to picking out carbs there are a couple that I would say are the go depending on if you want simple or complex carbs. Sweet potatoes are my favorite but for those who don’t like those there is brown or white rice. There is also whole wheat pasta & breads. You can’t forget to add in enough healthy fats which many do because they think of fat as being a bad thing. Healthy fats can be found in olive oil, almonds, natural peanut butter, and avocados. Although many hate veggies they are also a must to eat along with the other foods to get enough fiber. Those foods include broccoli, asparagus, green beans, brussel sprouts.

While there are not a ton of choices of food above, those are just a base line to get you started. There are many other options out there to eat healthy. You have to find the right food that you can enjoy eating and still be healthy. Find the right combination that works for you and have fun with it.

]]> 10 Best Non-Stimulant Fat Burners https://redcon1online.com/fat-burners/ Wed, 26 Apr 2017 04:00:55 +0000 https://redcon1online.com/?p=3394 10 Best Non-Stimulant Fat Burners

If you are an athlete, or anyone interested in fitness for that matter, you undoubtedly want to lose fat. The reason? It’s simple; as you lose fat, you are able to display your hard earned muscle mass, making it more obvious that you “work out”. Of course, saying you want to lose weight is just the tip of the iceberg, it’s a world of work, and often a lot of energy and cash has to be spent as well.

Which brings us to the next point- choosing a fat burner supplement to help speed things along.

Most popular fat burners are stimulant based, meaning that they contain one or more ingredients that stimulate the nervous system, with or without accompanying changes in heart rate and adrenalin release.

Then there is the category of fat burners that are classified as stimulant free, meaning that they do not contain ingredients which elevate nervous system activity, along with other similar traits.

So which is better? Over the short haul, stimulant fat burners. But if you want a safer, longer-term solution, non- stim fat burners are the winners by a long shot.

Not convinced? Here are a few short reasons why stimulant based fat burners are not the best option for your overall well-being:

  1. Stimulant Based Fat Burners Lose Potency Fast: most stimulant based fat burners contain significant amounts of caffeine, to which you quickly develop tolerance and its effects wear off. You may find yourself tempted to take higher and higher doses, although that is the worst possible thing you could do.
  2. They Are Not The Safest Fat Burners Out There: all stimulant fat burners carry the warning of consulting a physician prior to use because not everyone responds well to them. They have the potential of raising blood pressure or heart rate, which may be dangerous to people with pre-existing heart conditions (whether or not they know they have a condition).
  3. They Can Disrupt Your Sleep Patterns: stimulant based fat burners when taken too late in the afternoon will likely result in insomnia and sleep loss. Unless you have already developed a tolerance to the caffeine it in, this alone is a deal breaker for many people.
  4. Many Individuals Are Stimulant Insensitive: the symptoms of intolerance may manifest as increased anxiety and jitters, mental and psychological confusion or aggression, or in worst case scenarios can bring up hallucinations and psychoses.

There are many more reasons why stimulant based fat burners may not be right for you, but at the end of the day, your health should be the primary consideration.

Enter non-stimulant fat burners. These supplements can be a godsend, as they can be used for longer periods of time, and are much safer than heavy stimulant varieties. Look out for supplements containing the following ingredients, as they deliver the best bang for your hard earned buck!

Carnitine

Starting off with carnitine (which may occur as L-carnitine or acetyl l-carnitine), this is a versatile amino acid that improves the rate of oxidation of fatty acids in the muscle cell mitochondria by facilitating transport of fat into it. Though most people may not fully understand fat loss, this is the essence of it; triglycerides and stored body fat need to be converted into free fatty acids before they are “burned” by the mitochondria in the muscle cells. Carnitine is a useful addition to any fat loss supplement regimen, as it can also reduce the time before fatigue, and suppress appetite as well.  Carnitine does occur naturally in some foods, but if you want to accelerate the amount of fat you lose, a supplement is the way to go.

Conjugated Linoleic Acid (CLA)

Conjugated linoleic acid (CLA) is a derivative of the omega-6 fatty acid, linoleic acid. CLA occurs naturally in foods such as milk and beef, but the amount you can realistically get is way too low. CLA is fast catching on around the world, thanks to its ability to increase fat loss, without the cost incurred by potent stimulants. CLA is believed to bring about weight loss via multiple mechanisms, ranging from reducing appetite to promoting the utilization of fat for fuel, and preventing production and storage of new fat. Supplemental CLA is made from modified safflower or sunflower oil.

Dandelion Root Extract

Though dandelion root extract does not result in “direct” fat loss, it is a useful addition to bringing about weight reduction as a whole. Primarily, dandelion root supports the removal of excess water weight, due to its diuretic properties, and promotes detoxification and healthy digestion. If waste is not being processed in a timely manner, other metabolic functions can be negatively affected, resulting in but not limited to intestinal bloating. Ensure you drink enough water while using a supplement with dandelion root, or dehydration could be a result.

Alpha Lipoic Acid

Alpha lipoic acid is an impressive fat based compound, which can facilitate fat loss in many ways. For one, is the fact that alpha lipoic acid (ALA) has an appetite suppressing effect, enabling you to consume fewer calories throughout the day. ALA also has the ability to “partition nutrients”, which simply means that it guides carbohydrates to preferentially enter muscle cells, as opposed to being stored as fat.

ALA’s benefits don’t stop there, however, as it also helps promote glucose use, especially noteworthy in obese or diabetic individuals who may have insulin issues that limit weight loss. Finally, is ALA’s antioxidant effects. Weight loss involves important oxidative processes, which can negatively affect other organ systems as a result. The anti-oxidant effect of this supplement helps buffer adverse outcomes, and can even reverse markers of ageing!

3,5′-Diiodo-L-Thyronine

Related to the body’s natural thyroid hormone, 3,5′-Diiodo-L-Thyronine can be a great non-stimulant addition to a weight loss supplement plan as it ramps up your resting metabolic rate, along with increased rate of fat oxidation. This will result in a greater percentage of calories burned from fat, even while at rest doing absolutely nothing. Of course, that doesn’t mean that you should be doing nothing, as we know exercise drastically speeds up the rate at which weight is lost.

There were worries that 3,5′-Diiodo-L-Thyronine might be suppressive of natural thyroid hormone production, but the effect it has is likely to be mild, plus the fact that thyroid hormone function recovers fast following cessation of the supplement.

Sesamin

Sesamin is a compound known as lignin, found primarily in sesame seeds, but also other grain-based foods such as oats and flax. Sesamin is able to increase the activity of liver enzymes involved in the metabolism of fat, which helps to both increase fat use and reduces storage.  It is also believed to be able to spare muscle tissue, especially on lower caloric diets or on a carb restricted diet.

Finally, Sesamin purportedly has mild estrogen inhibiting effects, blocking the effect of estrogen on its receptors in fat cells. Estrogen is a fat-sparing hormone, so decreasing its influence on the fat cells allows it to undergo oxidation freely.

Choline

Choline is a water soluble, vitamin like compound that has numerous important functions in human biology.  Of interest to us, is the fact that Choline is a lipotropic agent, promoting fat oxidation in the liver. By itself, choline is pretty weak, but it is commonly used in conjunction with carnitine, in a synergistic manner.  When the two are used together, fat “flushing” is boosted, which is the excretion of fatty acid molecules joined to carnitine in urine (these compounds are known as acylcarnitine).

Garcinia Cambogia

You may have heard of this supplement somewhere in the last 5-10 years, thanks in large part to the presence of a compound known as hydroxy citric acid (HCA). HCA is believed to work by preventing the conversion of carbohydrates into fat compounds, and by reducing appetite. HCA is best taken on an empty stomach, as it may bind to certain foods and become inactivated by it.

Inositol

A sugar alcohol, Inositol is another lipotropic compound that promotes the utilization of fat by the liver, may prevent storage of fat and boosting the effects of neurotransmitters, including norepinephrine (noradrenaline) which is important in weight loss. Inositol is widely found throughout nature and works well in combination with B vitamins

Exogenous Ketones

Ketone supplements is an exciting new area of sports supplementation. The body naturally produces ketones for fuel instead of glucose during fasting or when following a ketogenic or low carb diet. Ketones are derived from dietary fat or body fat and are a more efficient fuel for the brain, heart and many other organs when compared to glucose.

In fact, fueling your body on ketones can substantially increase endurance, fat burning capabilities as well as lower heart rate and oxygen consumption. The ketogenic diet is pretty extreme (70-80% calories from fat) compared to our modern high carb diets. Exogenous ketone supplements offer a solution where you can reap the benefits of ketones, without following a super strict ketogenic diet.

Since ketone energy is derived from fat, supplementing with ketone supplements in-between meals will prime your body for using its body fat for fuel rather than glucose. For best results, use exogenous ketones with intermittent fasting and prefer low GI (glycemic index) carbs at mealtimes.

Seaweeds

Maybe one of the least expected fat burning ingredients on this list is seaweeds. Incredibly popular in Japanese cuisine such as sushi, seaweeds are the salad of the ocean and pack an amazing variety of health benefits. However, for this article, we are only interested in one of them, and that is its fat burning capabilities.

The carotenoid Siphonaxanthin in green algae was very recently proven to have potent anti-fat activity. In an animal study, Siphonaxathin was able to reduce adipose tissue weight by 13% with only 6 weeks of use. It was able to inhibit the development of fat cells and fat in tissues and is being speculated as a new potent ingredient for weight management. Carotenoids are antioxidant compounds which many of us already know of from foods such as carrots and tomatoes, where carotenoids are responsible for their bright orange and red colors.

However, Siponaxanthin is not the first component of seaweeds that has been proven to help you burn more fat; Fucoidan is one that is already available as supplements. Fucoidan is a complex of polysaccharides which are complex sugars which are essential for cellular communication in the body. They have been implicated in cancer research since they can promote apoptosis of cancer cells and make them self-destruct. Similar to Siponaxanthin, Fucoidan is also effective as a treatment against obesity.

Fucoidan stimulates the breakdown of fats; increasing metabolism and helping you burn more calories and in the end lose more weight. Fucoidan also contains significant amounts of the mineral iodine, which is critical for thyroid health. As many might be aware of, thyroid health greatly affects metabolism and fat burning capabilities. Hypothyroid is a condition of impaired and lowered thyroid function which makes it tough to burn fat because of low metabolism. If you struggle with weight loss even when on a calorie deficient, getting your thyroid checked out might be a good idea. To promote thyroid health as well as weight loss, Fucoidan is a great supplement to take.

Wrapping Up

There are dozens of non-stimulant fat burners for you to choose from, but when possible it is advisable to stack them in order to experience true synergistic weight loss. Stimulant fat burners contain one or more caffeine-like compounds, known as methlyxanthines, and should not be used for periods longer than 8 weeks.

Non-stim fat burners are safer for long term use, and you are unlikely to experience a crash of any kind after cessation of use or rebound weight gain. Give our SILENCER  product a try and save yourself the trouble of juggling multiple pills!

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