Although that is the only credible study I can attribute positive results on those fronts, we can play “connect the dots” with some other pieces of literature such as the ones done on TUDCA supplementation in correlation to glucose metabolism. A study done in 2006 (5) linked endoplasmic reticulum stress to obesity, insulin resistance, and diabetes. They state” here, we provide evidence that this mechanistic link can be exploited for therapeutic purposes with orally active chemical chaperones. 4-Phenyl butyric acid and taurine-conjugated ursodeoxycholic acid alleviated ER stress in cells and whole animals. Treatment of obese and diabetic mice with these compounds resulted in normalization of hyperglycemia, restoration of systemic insulin sensitivity, resolution of fatty liver disease, and enhancement of insulin action in liver, muscle, and adipose tissues. Our results demonstrate that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes.” Another study along similar lines of endoplasmic reticulum stress and its correlation to insulin resistance looked at glucose-induced beta cell dysfunction in vivo in rats which showed a link between oxidative stress and endoplasmic reticulum stress. Healthy Wistar rats were infused i.v. with glucose for 48 h to achieve 20 mmol/l hyperglycaemia with or without the co-infusion of the superoxide dismutase mimetic tempol (TPO), or the chemical chaperones 4-phenylbutyrate (PBA) or tauroursodeoxycholic acid (TUDCA). This was followed by assessment of beta cell function and measurement of ER stress markers and superoxide in islets. Glucose infusion for 48 h increased mitochondrial superoxide and ER stress markers and impaired beta cell function. Co-infusion of TPO, which we previously found to reduce mitochondrial superoxide and prevent glucose-induced beta cell dysfunction, reduced ER stress markers. Similar to findings with TPO, co-infusion of PBA, which decreases mitochondrial superoxide, prevented glucose-induced beta cell dysfunction in isolated islets. TUDCA was also effective. Also similar to findings with TPO, PBA prevented beta cell dysfunction during hyperglycaemic clamps in vivo and after hyperglycaemia (15 mmol/l) for 96 h. Here, we causally implicate ER stress in hyperglycaemia-induced beta cell dysfunction in vivo. We show that: (1) there is a positive feedback cycle between oxidative stress and ER stress in glucose-induced beta cell dysfunction, which involves mitochondrial superoxide; and (2) this cycle can be interrupted by superoxide dismutase mimetics as well as chemical chaperones, which are of potential interest to preserve beta cell function in type 2 diabetes (6.)
I could continue on and on about the benefits of TUDCA! Heck, we didn’t even cover the fact that bile acids have the ability to induce energy expenditure by promoting intracellular thyroid hormone activation (7.) But, I do feel I’ve presented enough pertinent information to prove TUDCA has its place in everyone’s supplement regimen given the fact that it is a potent health and ergogenic aid that is more than affordable. In terms of practical application, there have been studies done showing improvements of liver regenesis rates at a dosage as low as 10mgs and other studies showing benefits for muscle tissue insulin sensitivity and for the treatment of liver disease as high as almost 2000mgs. In actual application I personally recommend my clients (that are competitive athletes) to supplement with 250mgs of TUDCA per day year round. Then, during periods of high stress such as a contest prep or anytime you’re truly pushing your “supplements”, upwards of 1000mgs per day. You will obviously need to get bloodwork done to see where your liver enzyme levels are and how they change at what specific dosage to know for sure (once again, thank you biological inter-individuality!) I have also included four more studies linked below in the reference section for your academic pleasure (8, 9, 10, 11.) Please read more and make the decision for yourself if TUDCA is something that could be beneficial in your everyday supplement stack.
References
By Matt Samansky
Aaron Singerman is a name synonymous with supplements and success. But the lavish life of luxury cars and fine timepieces was not handed to him on a silver platter. In fact, the troubled young teen showed no signs of future achievement and was often labeled an “underachiever.” Join me as I take an in-depth look at the life (thus far) of the humble man who would become supplement industry royalty.
Aaron Singerman grew up in a suburb just outside of New Orleans where his father Jerry owned an upscale men’s clothing store. Aaron began working at the store from a young age and learned to appreciate the value of establishing a business and building upon it. By the time he reached high school, however, the Singerman family business had been replaced by a larger store with a nationwide reputation. Aaron worked many odd jobs throughout the remainder of his teens and into his 20’s; all of which he was fired from. This lack of direction coupled with poor social influences turned Aaron towards experimenting with drugs. It was not until a friend’s fatal overdose occurred in front of him that Aaron realized he had to make a change. But what changes could he make and which path would he take? Aaron always had a passion for weight training and a fascination with the sport of bodybuilding so he began working as a personal trainer. Aaron made a great deal of contacts whilst employed in this field and approached a co-worker driving a brand new Porsche. “How can I get a Porsche too?” asked the wide-eyed young Singerman. “You’ll never get a Porsche working here,” he responded. Not exactly the response Aaron was looking for, but he learned a valuable lesson that day. You can never be successful doing something you are not passionate about. This was the “eureka” moment that escaped Aaron for 20+ years. He finally knew what he had to do.
Aaron continued to train clients in order to pay the bills, but he spent all of his spare time listening to radio shows, reading books, immersing himself in the world of bodybuilding. One particular radio show Aaron subscribed to was Super Human Radio with Carl Lenore. Hoping to make a name for himself, Aaron wrote to Carl to inform him that one of the products he was endorsing would not work. Mr. Lenore was impressed by Aaron’s letter and asked him to conduct an interview on his show. The interview must have went well because he offered Aaron a steady gig hosting a bodybuilding focused show called Off Topic Radio. Aaron found advertisers and earned enough money from the show that he was able to quit personal training altogether. After recording 300+ hours of Off Topic, Aaron accepted a position with Rx Muscle, the world’s leading bodybuilding media site. He was eventually promoted to editor-in-chief, traveling the world covering bodybuilding shows and interviewing competitors. Aaron Singerman had achieved his dream but there was still so much more to accomplish.
Rx Muscle paid well, but Aaron was hungry for more. Utilizing his various contacts in the business and position in front of the camera, Aaron was able to make extra income wearing t-shirts and promoting products from outside sponsors. One such company was Iron Mag Labs, a company with which Aaron actually worked up the ranks so far that he achieved the distinction of marketing director. Along with friend and business partner PJ Braun, the two served as the collective “voice” of the company and more than doubled IML’s revenue.
Iron Mag Labs created Super DMZ, one of the most powerful supplements ever to grace supplement shelves. Company executives feared the product would soon become illegal due to gray market ingredients and expressed the desire to dispose of more than 7,000 units. Aaron saw the opportunity in this and purchased the remaining stock, assumed the risk and sold Super DMZ under the mysterious name of Blackstone Labs. In less than five weeks, their stock was depleted. The ingredient had not yet been banned so the duo of Aaron and PJ decided to continue with their money-making ways, this time re-branding Super DMZ and accompanying it with a second product, a third product, a fourth product, and so on. One year later, Aaron and PJ had become so successful with Blackstone Labs that they bought out their third investor and continued operations on their own.
Blackstone Labs quickly became the market leader in hardcore supplementation, but their target audience was limited. CEO Aaron recognized that certain Blackstone Labs supplements would not stay legal for long and growth could only be achieved through mainstream supplementation. It was then that Prime Nutrition was born. Products from this new sister company were results-based, appealing to the general fitness enthusiast. When retailers like Vitamin Shoppe and Bodybuilding.com found out Aaron Singerman and PJ Braun were the masterminds behind this new company, they jumped on the opportunity to work together. Blackstone Labs and Prime Nutrition quickly covered all aspects of the supplement business with two very different target customers; the latter appealing to the hardcore bodybuilder and the former to the general fitness person.
Blackstone Labs grew to such incredible heights that it was recently named to Inc. 500’s list of fastest growing companies in the United States. They finished at number 27 in the country and number 1 in their category.
Mr. Singerman had built a company from nothing to one of the top names in the industry. Most entrepreneurs would have been content with this achievement and continued on, but Aaron decided to challenge himself once again. In May of 2016, Aaron parted ways with Blackstone Labs to start a new adventure with Singerman Enterprises.
Under the Singerman Enterprises umbrella are Run Everything Labs, Dynamik Muscle, Iron Addict’s Brand, and RedCon1; four of the industry’s brightest young supplement companies. By starting these companies, Aaron has had the opportunity to work with such fitness celebrities as Dana Linn and Rob Bailey, Kai Greene, and most recently, CT Fletcher!
Today, Mr. Singerman operates as CEO of RedCon1. Despite being a toddler in the supplement industry, it is making waves among the elite nonetheless. Whereas most supplement companies debut with a product or two, RedCon1 has unveiled more than a dozen since opening its doors just 5 short months ago.
Unwavering determination, wealth of knowledge, and unparalleled business acumen has led Aaron Singerman to become the supplement mogul he is today. I have followed Aaron from his humble first days at RxMuscle and have been fortunate enough to work with him throughout the years. All of these qualities and more make Aaron a wonderful boss and an ever better friend. It has been a pleasure going to battle with you, Aaron, and I am “the highest state of readiness” for whatever comes next!
]]>News from our Round Table. Dallas, Matt and Aaron shoot the shit and discuss muffins, body building and health in our first RedCon1 Round Table.
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]]>SOMAL 4
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]]>Back Variation – Catch Joe Bennett Go over a number of exercises that you normally don’t do but you should be doing to maximize your workouts. This Episodes features “Back Variation.”
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Notes From Matt
I’m really looking forward to going back down and finishing out prep with Dallas on Saturday. Part of us being a team is being together so I’ve missed that part of prep the past 9 days. Jordan and I will be down Saturday and it will be hands on the rest of the way!
Be sure to following along today on IG and Snapchat as we document the training day!
dallasmccarver and mattjansen8
training – Back
8-9 liters of water
Sea salting all meals / seasons fine
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Meal 1 Meal 2 Meal 3 |
Meal 4 Meal 5 Meal 6 |
Cardio
30 min HARD AM
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Training Back 1. Close grip Lat pulldown Triple Accumulation set 10 + ADD weight 10 + ADD weight 10 + ADD weight as many as possible Aiming to only hit failure on last add set. Using a total of 4 weights = 1 set 2 sets 2. Chest supported DB RDL 1 Arm Really focusing on pulling to waist and keeping momentum out of movement 4×8-12 straight heavy sets Working up to a max set of 12 and maintaining weight for all sets 3. Superset Seated low row Into Seated hammer high row 4 x 10-15 4. Lat pulldown tri set To chin Behind head 45 degree fixed position upper back pulldown 3 sets x 10 on each – 1 min rest after all 3 movements complete 5. Hyper extension 10 reps with 10 second hold on last rep – 10 second break Continuing this until 100 reps are complete |
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